Mechanism of Erzhi Tiangui prescription in treating female infertility based on network pharmacology / 中国药理学通报

ABSTRACT

To observe the intervention mecha-nism of Erzhi Tiangui prescription on female infertility from the perspective of network pharmacology, so as to provide systematic biological information and basis for the treatment of infertility in elderly women with tradi-tional Chinese medicine. Methods Based on network pharmacology, the main chemical constituents and ac-tion targets of Erzhi Tiangui prescription were searched, its biological pathway was analyzed, and its binding activity was predicted by molecular docking technique. Results A total of 159 active components were screened, with 283 corresponding targets, 1 078 female infertility related disease targets and 104 inter-section targets, mainly involving key target proteins such as PTGS2, ESR1, HSP90AA1, AR, NOS2, PPARG, NCOA2 and so on. The biological pathways mainly acted on PI3 K-Akt signaling pathway, MAPK signaling pathway and so on. Conclusions The study preliminarily explores the mechanism of Erzhi Tiangui prescription in regulating female infertility through multi-ways, multi-components and multi-targets, and its main active components are well combined with Mfn-1 and Mfn-2, which may play a therapeutic role in the treatment of infertility in elderly women.