The latest research progress of α7 nicotinic acetylcholine receptor in cholinergic anti-inflammatory pathway / 药学实践与服务

ABSTRACT

α7 nicotinic acetylcholine receptor (α7nAChR) belongs to nicotinic acetylcholine receptors (nAChRs), which is the key receptor in cholinergic anti-inflammatory pathway and plays an important role in the neural regulation of immune system. Recent studies have found that α7nAChR is also involved in the regulation of various physiological and pathological processes other than immunity, such as non-alcoholic fatty liver, angiogenesis, heart protection, etc. In addition, α7nAChR is closely related to energy metabolism in neurodegenerative diseases. This article reviews the role of α7nAChR in treating inflammation and improving energy metabolism, and the new direction of α7nAChR involved in therapy.