Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells / 대한배뇨장애요실금학회지
International Neurourology Journal
; : 182-187, 2016.
Article
en En
| WPRIM
| ID: wpr-10454
Biblioteca responsable:
WPRO
ABSTRACT
Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5'-AMP-activated protein kinase (AMPK) activators such as 5'-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or the hypoglycemic agent metformin. We found that AICAR or metformin acts as a regulator of LPS/NF-κB-or hypoxia/NF-κB-mediated cyclooxygenase induction by an AMPK-dependent mechanism with interactions between p65-NF-κB phosphorylation and acetylation, including in a human bladder cancer cell line (T24). In summary, we highlighted the regulatory interactions of AMPK activity on NF-κB induction, particularly in posttranslational phosphorylation and acetylation of NF-κB under inflammatory conditions or hypoxia environment.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Fosforilación
/
Acetilación
/
Proteínas Quinasas
/
Vejiga Urinaria
/
Neoplasias de la Vejiga Urinaria
/
Línea Celular
/
Procesamiento Proteico-Postraduccional
/
Lipopolisacáridos
/
FN-kappa B
/
Prostaglandina-Endoperóxido Sintasas
Límite:
Humans
Idioma:
En
Revista:
International Neurourology Journal
Año:
2016
Tipo del documento:
Article