The Effect of Topiramate and Lamotrigine on Cerebral Glucose Metabolism in Idiopathic Generalized Epilepsy Patients / 대한간질학회지
Journal of Korean Epilepsy Society
; : 129-136, 2005.
Article
en Ko
| WPRIM
| ID: wpr-113453
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
To investigate the effects of topiramate (TPM) or lamotrigine (LTG) on cerebral glucose metabolism, we performed 18F-fluorodeoxy glucose positron emission tomography (FDG-PET) before and after medication in patients with drug naive idiopathic generalized epilepsy.METHODS:
Thiry-three patients with newly diagnosed as idiopathic generalized epilepsy (IGE) or IGE without antiepileptic drugs after diagnosis were included. Pre- and post-antiepileptic drug FDG-PET were performed (before and after TPM or LTG administration) in 33 subjects treated with TPM or LTG who had been seizure free for at least 8 weeks. Sixteen of patients received TPM (M/F=8/8, aged 29.2+/-12.3 years) and 17 LTG (M/F=8/9, 26.8+/-9.3 years). For statistical paramateric (SPM) analysis, all PET images were spatially normalized to the standard PET template and then smoothed using a 12-mm full width at half-maximum Gaussian kernel. The paired t-test was used to compare pre- and post-medication FDG-PET images.RESULTS:
SPM analysis of post- and pre-medication FDG-PETs showed TPM reduced glucose metabolism markedly in the thalamus, corpus callosum, and white matters, whereas LTG decreased glucose metabolism in cortico-striato-entorhinal areas with a false discovery rate corrected p<0.05. No brain region showed post-medication hypermetabolism in either group.CONCLUSION:
Our study demonstrates that both TPM and LTG affect the cerebral glucose metabolism in drug naive idiopathic generalized epilepsy patients.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Convulsiones
/
Tálamo
/
Encéfalo
/
Inmunoglobulina E
/
Epilepsia Generalizada
/
Cuerpo Calloso
/
Tomografía de Emisión de Positrones
/
Diagnóstico
/
Epilepsia
/
Glucosa
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Ko
Revista:
Journal of Korean Epilepsy Society
Año:
2005
Tipo del documento:
Article