Participation of IL-1β in temporomandibular nociception in rats with CFA-induced inflammation
International Journal of Oral Biology
; : 125-131, 2016.
Article
en Ko
| WPRIM
| ID: wpr-124490
Biblioteca responsable:
WPRO
ABSTRACT
The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced TMJ nociception. Experiments were carried out using male Sprague-Dawley rats. Intra-articular injection of 3% formalin was administered to evaluate hyperalgesia 3 days after CFA injection. Intra-articular injection of 3% formalin did not produce nociceptive behavior in normal rats. Although intra-articular injection of 3 doses of CFA produced TMJ inflammation, only 13 diluted CFA produced hyperalgesia when formalin was injected intra-articularly 3 days after CFA injection. Co-administration of IL-1 receptor inhibitor with formalin into the TMJ cavity 3 days after CFA injection was performed. Co-administration of IL-1 receptor inhibitor significantly inhibited formalin-induced hyperalgesia in rats with CFA-induced TMJ inflammation. These results suggested that intra-articular injection of formalin produced hyperalgesia under chronic TMJ inflammation. Moreover, IL-1β plays an important role in TMJ hyperalgesia under chronic inflammation and blockade of IL-1β is a potential therapeutic target for inflammatory TMJ pain.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Articulación Temporomandibular
/
Interleucina-1
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Ratas Sprague-Dawley
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Modelos Animales
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Nocicepción
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Formaldehído
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Hiperalgesia
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Inflamación
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Inyecciones Intraarticulares
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
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Male
Idioma:
Ko
Revista:
International Journal of Oral Biology
Año:
2016
Tipo del documento:
Article