Heparin Resistance during Cardiopulmonary Bypass in Infective Endocarditis Patients: A case report / 대한마취과학회지
Korean Journal of Anesthesiology
; : 868-871, 2005.
Article
en Ko
| WPRIM
| ID: wpr-144202
Biblioteca responsable:
WPRO
ABSTRACT
Appropriate anticoagulation is essential for safe cardiopulmonary bypass (CPB). Two patients with infective endocarditis were scheduled for valve replacement. After an intravenous heparin injection for the CPB, the increases in the activated clotting time (ACT) in both patients were less than expected. Subsequent additional heparin administration failed to maintain a sufficient ACT for the CPB, and antithrombin III (AT III) tests during the CPB revealed low activities in both patients. Heparin resistance, due to consumption of circulating AT III as a result of infective endocarditis or prior heparinization, was postulated. While fresh frozen plasma (FFP) could not be timely administered in the first patient, ACT was successfully prolonged after the administration of FFP in the second. It is strongly suggested that adequate management of heparin resistance should be prepared for patients with infective endocarditis who require CPB.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plasma
/
Heparina
/
Puente Cardiopulmonar
/
Antitrombina III
/
Deficiencia de Antitrombina III
/
Endocarditis
Límite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Anesthesiology
Año:
2005
Tipo del documento:
Article