Caudate Volume Change in Transient Global Amnesia Patients; Voxel-Based Morphometric Study
Journal of the Korean Neurological Association
; : 199-204, 2011.
Article
en Ko
| WPRIM
| ID: wpr-145209
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Transient global amnesia (TGA) is characterized by a severe disturbance of memory, lasting less than a day, and complete resolution. However, some authors have suggested the occurrence of permanent memory impairment in such cases. In this study, we investigated whether the gray-matter structure suffers degeneration in TGA, based on the assumption that TGA attacks appear to be related to underlying permanent pathology.METHODS:
T1-weighted magnetic resonance imaging data for 20 TGA and 55 normal subjects were analyzed. The gray-matter volume was measured using voxel-based morphometry. The subjects also completed the Seoul Neuropsychological Screening Battery (SNSB).RESULTS:
The gray-matter volume was reduced in the left superior frontal gyrus, right precentral gyrus, right superior frontal gyrus, left caudate nucleus, left precentral gyrus, left post central gyrus, and both putamens. The SNSB revealed the presence of selective neuropsychological dysfunctions after clinical recovery. Most of the cases exhibited attention deficit, and difficulties in copying of the Rey-Osterrieth Complex Figure, and in the Seoul verbal learning test.CONCLUSIONS:
Left caudate nucleus atrophy could explain the attention deficit and memory impairment experienced in these TGA patients. Many patients with TGA have neuropsychological dysfunctions even after they appear to be clinically improved.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Putamen
/
Atrofia
/
Aprendizaje Verbal
/
Imagen por Resonancia Magnética
/
Núcleo Caudado
/
Tamizaje Masivo
/
Amnesia Global Transitoria
/
Proteína Coat de Complejo I
/
Memoria
Tipo de estudio:
Screening_studies
Límite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Neurological Association
Año:
2011
Tipo del documento:
Article