Expression of p63,bcl-2,bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin
Korean Journal of Pathology
; : 91-98, 2005.
Article
en En
| WPRIM
| ID: wpr-147996
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a reliable keratinocyte stem cell marker. Bcl-2 plays a key role in cell longevity by preventing apoptosis, whereas the bcl-6 gene functions as a transcriptional repressor. The p16-CDK4/6 complex arrests the cell cycle at G0 /G1 phase. In the present study, the expression of p63, bcl-2, bcl-6, and p16 in BCC and SCC was evaluated.METHODS:
Forty-seven BCCs and 43 SCCs were selected and microarrayed in paraffin blocks. Immunohistochemical analysis was performed with specific antibodies for bcl-2, bcl-6, p16 and p63.RESULTS:
p63 was found to be expressed in all BCCs and SCCs. Bcl-2 was exclusively expressed in BCCs (100%), but there was negative expression in SCCs, whereas bcl-6 was positively expressed in 18.2% of SCCs, and was negative in BCCs. In SCCs, p16 was expressed at high frequency (47.7%) than in BCCs (14.9%). The expression of p16 was correlated with the histologic grades of SCCs.CONCLUSION:
The different patterns of bcl-2, bcl-6, p63 and p16 protein expression between BCCs and SCCs may represent the different histogenesis and morphologic features of two lesions.Palabras clave
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Base de datos:
WPRIM
Asunto principal:
Parafina
/
Piel
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Células Madre
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Carcinoma Basocelular
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Carcinoma de Células Escamosas
/
Queratinocitos
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Ciclo Celular
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Apoptosis
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Proteínas Proto-Oncogénicas c-bcl-6
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Longevidad
Idioma:
En
Revista:
Korean Journal of Pathology
Año:
2005
Tipo del documento:
Article