The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group
Journal of Clinical Neurology
; : 393-402, 2016.
Article
en En
| WPRIM
| ID: wpr-150667
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE: Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients. METHODS: We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms. RESULTS: In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage. CONCLUSIONS: The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedad de Parkinson
/
Calidad de Vida
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Demografía
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Prevalencia
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Cognición
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Corea (Geográfico)
/
Trastornos del Movimiento
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Prevalence_studies
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Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Journal of Clinical Neurology
Año:
2016
Tipo del documento:
Article