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Use of 18F-FDG PET to predict tumor progression and survival in patients with intermediate hepatocellular carcinoma treated by transarterial chemoembolization
Article en En | WPRIM | ID: wpr-152282
Biblioteca responsable: WPRO
ABSTRACT
BACKGROUND/

AIMS:

18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG PET) has been used to assess the biological behavior of hepatocellular carcinoma (HCC). In this study, we investigated the usefulness of 18F-FDG PET for predicting tumor progression and survival in patients with intermediate Barcelona Clinic Liver Cancer (BCLC) intermediate-stage HCC treated by transarterial chemoembolization (TACE).

METHODS:

From February 2006 to March 2013, 210 patients treated with TACE, including 77 patients with BCLC intermediate-stage HCC, underwent examination by 18F-FDG PET. 18F-FDG uptake was calculated based on the tumor maximum (Tmax) standardized uptake value (SUV), the liver mean (Lmean) SUV, and the ratio of the Tmax SUV to the Lmean SUV (Tmax/Lmean).

RESULTS:

The mean follow-up period for the 77 patients (52 males, 25 females; average age, 63.3 years) was 22.2 months. The median time to progression of HCC in patients with a low Tmax/Lmean ( or = 1.83) was 17 and 6 months, respectively (p < 0.001). The median overall survival time of patients with a low and high Tmax/Lmean was 44 and 14 months, respectively (p = 0.003). Multivariate analysis revealed that the Tmax/Lmean was an independent predictor of overall survival (hazard ratio [HR], 1.96; 95% confidence interval [CI], 1.210 to 3.156; p = 0.006) and tumor progression (HR, 2.05; 95% CI, 1.264 to 3.308; p = 0.004).

CONCLUSIONS:

18F-FDG uptake calculated by the Tmax/Lmean using PET predicted tumor progression and survival in patients with BCLC intermediate-stage HCC treated by TACE.
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Texto completo: 1 Base de datos: WPRIM Asunto principal: Factores de Tiempo / Tomografía Computarizada por Rayos X / Modelos de Riesgos Proporcionales / Valor Predictivo de las Pruebas / Estudios Retrospectivos / Factores de Riesgo / Resultado del Tratamiento / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Progresión de la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: The Korean Journal of Internal Medicine Año: 2015 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Asunto principal: Factores de Tiempo / Tomografía Computarizada por Rayos X / Modelos de Riesgos Proporcionales / Valor Predictivo de las Pruebas / Estudios Retrospectivos / Factores de Riesgo / Resultado del Tratamiento / Quimioembolización Terapéutica / Carcinoma Hepatocelular / Progresión de la Enfermedad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: The Korean Journal of Internal Medicine Año: 2015 Tipo del documento: Article