Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection
Annals of Surgical Treatment and Research
; : 143-151, 2014.
Article
en En
| WPRIM
| ID: wpr-158581
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
Because predicting recurrence intervals and patterns would allow for appropriate therapeutic strategies, we evaluated the clinical and pathological characteristics of early and late recurrences of colorectal cancer.METHODS:
Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I-III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups.RESULTS:
One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 (CA 19-9), venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence (40.5%), whereas late recurrence was more common locally (28.1%), or in the lung (32.8%). The 5-year overall survival rates for early and late recurrence were significantly different (34.7% vs. 78.8%; P < 0.001). Survival rates after the surgical resection of recurrent lesions were not different between the two groups.CONCLUSION:
Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
/
Recurrencia
/
Neoplasias Colorrectales
/
Análisis Multivariante
/
Tasa de Supervivencia
/
Factores de Riesgo
/
Hígado
/
Pulmón
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Año:
2014
Tipo del documento:
Article