Mucosal dendritic cells shape mucosal immunity
Experimental & Molecular Medicine
; : e84-2014.
Article
en En
| WPRIM
| ID: wpr-161403
Biblioteca responsable:
WPRO
ABSTRACT
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs for the development of efficient mucosal vaccines to protect against infectious diseases.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Células Dendríticas
/
Linfocitos T Colaboradores-Inductores
/
Inmunidad Mucosa
/
Mucosa Intestinal
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2014
Tipo del documento:
Article