Successful Treatment of Alopecia Areata with Topical Calcipotriol
Annals of Dermatology
; : 341-344, 2012.
Article
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| WPRIM
| ID: wpr-173377
Biblioteca responsable:
WPRO
ABSTRACT
Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vitamin D-resistant rickets, or vitamin D receptor (VDR) mutation. The biological actions of vitamin D3 derivatives include regulation of epidermal cell proliferation and differentiation and modulation of cytokine production. These effects might explain the efficacy of vitamin D3 derivatives for treating AA. In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Vitamina D
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Deficiencia de Vitamina D
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Calcitriol
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Calcio
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Receptores de Calcitriol
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Colecalciferol
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Proliferación Celular
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Alopecia
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Alopecia Areata
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Raquitismo Hipofosfatémico Familiar
Límite:
Child
/
Humans
Idioma:
En
Revista:
Annals of Dermatology
Año:
2012
Tipo del documento:
Article