Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication
Journal of Korean Medical Science
; : 1441-1449, 2014.
Article
en En
| WPRIM
| ID: wpr-174934
Biblioteca responsable:
WPRO
ABSTRACT
Paraquat (PQ) has known negative human health effects, but continues to be commonly used worldwide as a herbicide. Our clinical data shows that the main prognostic factor is the time required to achieve a negative urine dithionite test. Patient survival is a 100% when the area affected by ground glass opacity is <20% of the total lung volume on high-resolution computed tomography imaging 7 days post-PQ ingestion. The incidence of acute kidney injury is approximately 50%. The average serum creatinine level reaches its peak around 5 days post-ingestion, and usually normalizes within 3 weeks. We obtain two connecting lines from the highest PQ level for the survivors and the lowest PQ level among the non-survivors at a given time. Patients with a PQ level between these two lines are considered treatable. The following treatment modalities are recommended to preserve kidney function 1) extracorporeal elimination, 2) intravenous antioxidant administration, 3) diuresis with a fluid, and 4) cytotoxic drugs. In conclusion, this review provides a general overview on the diagnostic procedure and treatment modality of acute PQ intoxication, while focusing on our clinical experience.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Paraquat
/
Tomografía Computarizada por Rayos X
/
Quelantes del Hierro
/
Hemoperfusión
/
Creatinina
/
Lesión Renal Aguda
/
Herbicidas
/
Enfermedades Pulmonares
/
Antioxidantes
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Article