Acute generalized exanthematous pustulosis presumed to be caused by acetaminophen
Allergy, Asthma & Respiratory Disease
; : 52-55, 2017.
Article
en Ko
| WPRIM
| ID: wpr-189592
Biblioteca responsable:
WPRO
ABSTRACT
Acute generalized exanthematous pustulosis (AGEP) is a severe and rare disease usually related to drug eruption. AGEP is induced by drugs in over 90% of cases with antibiotics being the most common. It is characterized by a fever and a pustular eruption on erythematous skin with acute onset and without follicular localization. Acetaminophen is commonly used as an antipyretic and analgesic. Acetaminophen has been reported to be an uncommon cause of AGEP. We report a 79-year-old woman presenting with fever and erythematous maculopapular eruptions on the trunk with sterile pustules arising upon the use of acetaminophen for back pain. Leukocytosis and elevated C-reactive protein levels were noted on the laboratory examination. The histopathological examination of the skin biopsy specimen showed intraepidermal pustule formation with superficial perivascular lymphocytic infiltration, including eosinophils, and extensive red blood cell extravasation. The lesions were resolved with discontinuation of acetaminophen and use of systemic corticosteroid. We report a case of AGEP probably caused by acetaminophen.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Piel
/
Biopsia
/
Proteína C-Reactiva
/
Erupciones por Medicamentos
/
Dolor de Espalda
/
Enfermedades Raras
/
Eosinófilos
/
Eritrocitos
/
Pustulosis Exantematosa Generalizada Aguda
/
Fiebre
Límite:
Aged
/
Female
/
Humans
Idioma:
Ko
Revista:
Allergy, Asthma & Respiratory Disease
Año:
2017
Tipo del documento:
Article