HOTAIR Long Non-coding RNA: Characterizing the Locus Features by the In Silico Approaches
Genomics & Informatics
; : 170-177, 2017.
Article
en En
| WPRIM
| ID: wpr-192014
Biblioteca responsable:
WPRO
ABSTRACT
HOTAIR is an lncRNA that has been known to have an oncogenic role in different cancers. There is limited knowledge of genetic and epigenetic elements and their interactions for the gene encoding HOTAIR. Therefore, understanding the molecular mechanism and its regulation remains to be challenging. We used different in silico analyses to find genetic and epigenetic elements of HOTAIR gene to gain insight into its regulation. We reported different regulatory elements including canonical promoters, transcription start sites, CpGIs as well as epigenetic marks that are potentially involved in the regulation of HOTAIR gene expression. We identified repeat sequences and single nucleotide polymorphisms that are located within or next to the CpGIs of HOTAIR. Our analyses may help to find potential interactions between genetic and epigenetic elements of HOTAIR gene in the human tissues and show opportunities and limitations for researches on HOTAIR gene in future studies.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Simulación por Computador
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Expresión Génica
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Islas de CpG
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Biología Computacional
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Polimorfismo de Nucleótido Simple
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Sitio de Iniciación de la Transcripción
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Epigenómica
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ARN Largo no Codificante
Límite:
Humans
Idioma:
En
Revista:
Genomics & Informatics
Año:
2017
Tipo del documento:
Article