A Case of von Hippel-Lindau Disease with Colorectal Adenocarcinoma, Renal Cell Carcinoma and Hemangioblastomas / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 409-414, 2016.
Article
en En
| WPRIM
| ID: wpr-20749
Biblioteca responsable:
WPRO
ABSTRACT
von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome associated with mutations of the VHL tumor suppressor gene located on chromosome 3p25. The loss of functional VHL protein contributes to tumorigenesis. This condition is characterized by development of benign and malignant tumors in the central nervous system (CNS) and the internal organs, including kidney, adrenal gland, and pancreas. We herein describe the case of a 74-year-old man carrying the VHL gene mutation who was affected by simultaneous colorectal adenocarcinoma, renal clear cell carcinoma, and hemangioblastomas of CNS.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Páncreas
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Carcinoma de Células Renales
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Neoplasias Colorrectales
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Adenocarcinoma
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Sistema Nervioso Central
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Genes Supresores de Tumor
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Glándulas Suprarrenales
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Hemangioblastoma
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Carcinogénesis
/
Enfermedad de von Hippel-Lindau
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Cancer Research and Treatment
Año:
2016
Tipo del documento:
Article