Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
Endocrinology and Metabolism
; : 252-262, 2015.
Article
en En
| WPRIM
| ID: wpr-215489
Biblioteca responsable:
WPRO
ABSTRACT
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated with the mitogen-activated protein kinase pathway. B-Raf proto-oncogene (BRAF) mutations are the most common mutations observed in papillary thyroid cancers (PTCs), followed by RET/PTC rearrangements and RAS mutations, while follicular thyroid cancers are more likely to harbor RAS mutations or PAX8/peroxisome proliferator-activated receptor gamma (PPARgamma) rearrangements. Beyond these more common mutations, alterations in the telomerase reverse transcriptase (TERT) promoter have recently been associated with clinicopathologic features, disease prognosis, and tumorigenesis in thyroid cancer. While the mutations underlying thyroid tumorigenesis are well known, the frequency of these mutations is strongly associated with geography, with clear differences reported between Asian and Western countries. Of particular interest is the prevalence of BRAF mutations, with Korean patients exhibiting the highest rate of BRAF-associated thyroid cancers in the world. Here, we review the prevalence of each of the most common mutations in Asian and Western countries, and identify the characteristics of well-differentiated thyroid cancer in Asians.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
/
Proteínas Quinasas
/
Asia
/
Glándula Tiroides
/
Proto-Oncogenes
/
Neoplasias de la Tiroides
/
Prevalencia
/
Telomerasa
/
Pueblo Asiatico
/
Proteínas Proto-Oncogénicas B-raf
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Endocrinology and Metabolism
Año:
2015
Tipo del documento:
Article