Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules
Immune Network
; : 37-43, 2015.
Article
en En
| WPRIM
| ID: wpr-220544
Biblioteca responsable:
WPRO
ABSTRACT
It is well established that TGF-beta1 and retinoic acid (RA) cause IgA isotype switching in mice. We recently found that lactoferrin (LF) also has an activity of IgA isotype switching in spleen B cells. The present study explored the effect of LF on the Ig production by mouse peritoneal B cells. LF, like TGF-beta1, substantially increased IgA production in peritoneal B1 cells but little in peritoneal B2 cells. In contrast, LF increased IgG2b production in peritoneal B2 cells much more strongly than in peritoneal B1 cells. LF in combination with RA further enhanced the IgA production and, interestingly, this enhancement was restricted to IgA isotype and B1 cells. Similarly, the combination of the two molecules also led to expression of gut homing molecules alpha4beta7 and CCR9 on peritoneal B1 cells, but not on peritoneal B2 cells. Thus, these results indicate that LF and RA can contribute to gut IgA response through stimulating IgA isotype switching and expression of gut-homing molecules in peritoneal B1 cells.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Bazo
/
Tretinoina
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Inmunoglobulina A
/
Inmunoglobulina G
/
Linfocitos B
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Cambio de Clase de Inmunoglobulina
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Factor de Crecimiento Transformador beta1
/
Lactoferrina
Límite:
Animals
Idioma:
En
Revista:
Immune Network
Año:
2015
Tipo del documento:
Article