The Effect of a Topical Selective Cyclooxygenase-2 Inhibitor on Skin-Wound Scarring of the Rabbit Ear
Journal of the Korean Society of Plastic and Reconstructive Surgeons
; : 351-358, 2011.
Article
en En
| WPRIM
| ID: wpr-224769
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
The inflammatory phase is considered an integral part of adult wound healing, but fetal wound healing studies have shown scarless healing results in the absence of the inflammation process. The COX-2 pathway is an essential component of inflammation. The purpose of this study is to identify the effect of a topical selective COX-2 inhibitor on inflammation in rabbit skin wound healing and scarring.METHODS:
Full-thickness wounds were made on 6 New Zealand rabbits' ears. Topical 5% celecoxib + vehicle (experimental tissue) and vehicle only (controlled tissue) were applied daily for 14d on each side of the ears. Scar samples were harvested at 2 wks, 4 wks, and 8 wks after the wounding. Each sample was stained with hematoxylin and eosin and the Masson's trichrome stain to evaluate inflammation and scar formation.RESULTS:
Histological analysis demonstrated a significant reduction of inflammation, neovascularization, and scar elevation in the experimental tissue as compared to the control. Additionally, experimental tissue exhibited faster improvement of collagen organization similar to that of normal tissue.CONCLUSION:
This study suggests that the topical application of a selective COX-2 inhibitor on a rabbit ear wound resulted in decreased inflammation and had a positive effect on the reduction of scar formation.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pirazoles
/
Piel
/
Sulfonamidas
/
Compuestos Azo
/
Cicatrización de Heridas
/
Colágeno
/
Cicatriz
/
Inhibidores de la Ciclooxigenasa
/
Eosina Amarillenta-(YS)
/
Oído
Límite:
Adult
/
Humans
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Journal of the Korean Society of Plastic and Reconstructive Surgeons
Año:
2011
Tipo del documento:
Article