An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 431-436, 2007.
Article
en Zh
| WPRIM
| ID: wpr-230574
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the economic evaluation of short- and long-term antiviral treatments of HBeAg-positive chronic hepatitis B from the perspective of the Chinese health care system.</p><p><b>METHODS</b>A 10-health state Markov model was developed to estimate long-term cost and effectiveness of different treatments of HBeAg-positive CHB. Incremental cost-effectiveness analysis was then carried out.</p><p><b>RESULTS</b>In comparison with no antiviral treatment, lamivudine administered for 1-year was a highly cost-effective short-course treatment for HBeAg-positive CHB. However, of the treatments evaluated, lamivudine plus adefovir as a rescue medication or adefovir plus lamivudine as a rescue medication administered for 5 years resulted in a more sustained decrease in the rate of disease progression. In comparison with 1 year lamivudine treatment, the incremental cost per Quality Adjusted Life Year (QALY) for treatment with lamivudine plus adefovir or adefovir plus lamivudine as a rescue medication for 5 years was CNY 25 115 and 35 577 respectively, which was 55.2% and 36.5% lower than the estimated international threshold value for China.</p><p><b>CONCLUSION</b>In comparison with no antiviral treatment, lamivudine administered for 1-year is a highly cost-effective short-course treatment. Longer duration antiviral treatments, lamivudine plus adefovir or adefovir plus lamivudine as a rescue medication are both cost-effective strategies, resulting in a more sustained decrease in the rate of disease progression.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Antivirales
/
Sangre
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Adenina
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Resultado del Tratamiento
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Análisis Costo-Beneficio
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Años de Vida Ajustados por Calidad de Vida
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Lamivudine
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Hepatitis B Crónica
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Usos Terapéuticos
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Quimioterapia
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Límite:
Female
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Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Año:
2007
Tipo del documento:
Article