Physical and chemical characteristics of a new cefazolin sodium hydrate crystal / 药学学报
Acta Pharmaceutica Sinica
; (12): 868-872, 2008.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-232675
Biblioteca responsable:
WPRO
ABSTRACT
One kind of new cefazolin sodium hydrate crystal was obtained in the isopropyl alcohol - water system. There are two symmetry independent molecules in the asymmetric unit, both being well ordered in the lattice, and ten independent water positions but generally four to six (mean five) water molecules and one sodium ion present in the unit cell structure. Huge solvent tunnels can be found. Again there are two general regions of water molecules, those in the large solvent tunnels and those in proximity of the sodium ion and the tetrazole moieties of the drug molecule. The physical and chemical characteristics of the new cefazolin sodium hydrate crystal are similar to that of the alpha-form cefazolin sodium crystal, and the new crystal has better chemical stability than amorphous cefazolin sodium powder.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Sodio
/
Espectrofotometría Atómica
/
Agua
/
Estructura Molecular
/
Cefazolina
/
Química
/
Cristalografía por Rayos X
/
Cristalización
/
Estabilidad de Medicamentos
/
Antibacterianos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo