Investigation of B-cell activating factor in serum and cerebrospinal fluid of patients with neuromyelitis optical / 南方医科大学学报
Journal of Southern Medical University
; (12): 380-383, 2015.
Article
en Zh
| WPRIM
| ID: wpr-239173
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of B-cell activating factor (BAFF) in the serum and cerebrospinal fluid of patients with neuromyelitis optical (NMO).</p><p><b>METHODS</b>Clinical data were collected from 44 patients with NMO and 38 patients with multiple sclerosis (MS). Thirty healthy controls and 15 controls with noninflammatory neurological diseases were also recruited. The concentration of BAFF in the serum and cerebrospinal fluid were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The mean serum BAFF level was 250.2 ± 126.9 pg/ml in NMO patients, 249.6 ± 130.7 pg/ml in MS patients, and 222.9 ± 126.1 pg/ml in the control subjects, showing no significant difference among the 3 groups (P>0.05). The mean BAFF level in the CSF was significantly higher in NMO patients than in MS patients (525.8 ± 230.0 pg/ml vs 298.4 ± 141.9 pg/ml, P<0.05), and higher in MS patients than in the control subjects (141.4 ± 76.2 pg/ml, P<0.05). Both NMO and MS group showed a positive correlation between EDSS scores and CSF BAFF level. But in NMO patients, CSF BAFF level was not associated with AQP4-antibody titer.</p><p><b>CONCLUSION</b>BAFF in the CSF may be a useful biomarker for a differential diagnosis of NMO from MS and has an important value in evaluating the disease severity.</p>
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1
Base de datos:
WPRIM
Asunto principal:
Sangre
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Ensayo de Inmunoadsorción Enzimática
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Biomarcadores
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Estudios de Casos y Controles
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Líquido Cefalorraquídeo
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Neuromielitis Óptica
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Diagnóstico Diferencial
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Factor Activador de Células B
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Esclerosis Múltiple
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2015
Tipo del documento:
Article