Characteristics of Transient Lower Esophageal Sphincter Relaxation in Healthy Korean Adults / 대한소화관운동학회지
Korean Journal of Gastrointestinal Motility
; : 180-187, 2000.
Article
en Ko
| WPRIM
| ID: wpr-24373
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Transient lower esophageal sphincter relaxation (tLESR) is the main cause of gastroesophageal reflux (GER) in both healthy subjects and patients with GER disease. Unfortunately, we have no data on tLESR and its relationship with GER in Korea. Therefore, this study was performed to evaluate the characteristics of tLESR in Korean subjects and the mechanisms of GER after Korean meals.METHODS:
Eight healthy volunteers (8 men, 23 to 25 yrs) received a Korean meal (laver-rolled rice, fried egg, sweet rice juice, 640 Kcal). A mylohyoid electromyogram, LES pressure using a Dent sleeve and esophageal pH were simultaneously recorded for 1 hour while fasting and 3 hours after the meal. We compared the manometric profile of swallow-induced LES relaxation (sLESR) with the manometric profile of tLESR and evaluated the frequency of tLESR and reflux episodes, and their relationship.RESULTS:
Compared with sLESR, tLESR showed longer time onset to completion, slower relaxation rate, longer duration of relaxation, and a lower nadir pressure. Incidence of tLESR increased after the meal, which was mostly accompanied by GER. Also, the frequency of GER increased after the meal, which mostly occurred during tLESR.CONCLUSIONS:
Our results suggest that tLESR is a main cause of GER in healthy Korean adults, which is a similar result to studies of Westerners.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Óvulo
/
Relajación
/
Reflujo Gastroesofágico
/
Incidencia
/
Ayuno
/
Esfínter Esofágico Inferior
/
Comidas
/
Voluntarios Sanos
/
Concentración de Iones de Hidrógeno
/
Corea (Geográfico)
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
Límite:
Adult
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Gastrointestinal Motility
Año:
2000
Tipo del documento:
Article