Demonstration of nested case-control study design in mechanisms research of allergic reaction of tanreqing injection / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3567-3570, 2014.
Article
en Zh
| WPRIM
| ID: wpr-244522
Biblioteca responsable:
WPRO
ABSTRACT
The paper is focused on the clinical applications of Tanreqing injection after listing, detecting and analyzing the related blood indicators of patients with allergic reactions based on prospective, multi-center, large sample, registration-type clinical safety monitoring nested case-control study (NCCS) to explore the possible mechanisms of allergic reaction of Tanreqing injection, 3 006 patients cases used with Tanreqing injection were monitored, including 3 cases of adverse reactions and 2 cases of allergic reactions. Each patient of allergic reactions, according to the ratio of 14 matches four cases of not adverse reactions as a control group of patients, while 5 healthy and 5 cases of volunteers into the healthy group. We examined the correlation detection of cases of allergic reactions among groups such as T-IgE, IgA, IgG, C3, C4, IFN-g, IL-2, IL-4, IL-6, IL-10. Allergic reactions of Tanreqing injection may be mediated by IgE as type I based on existing research data. This results and conclusions will promote the justifiability and safety of clinical applications.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Medicamentos Herbarios Chinos
/
Estudios de Casos y Controles
/
Estudios Prospectivos
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Interleucina-4
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Interleucina-6
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Interleucina-2
/
Interleucina-10
/
Diagnóstico
/
Hipersensibilidad
/
Metabolismo
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
/
Observational_studies
Límite:
Adolescent
/
Adult
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Female
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Humans
/
Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Article