Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 341-344, 2007.
Article
en Zh
| WPRIM
| ID: wpr-247319
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the mutations of BRCA1 in breast cancer patients of Uigur women in Xinjiang.</p><p><b>METHODS</b>By using single strand conformation polymorphism (SSCP) and DNA sequencing, BRCA1 mutations were detected in 70 Uigur women breast cancer cases and 32 cases of benign breast diseases and non-tumor tissue next to carcinoma.</p><p><b>RESULTS</b>(1) 12 new loci of BRCA1 gene mutation were detected firstly in 70 Uigur women breast cancer patients. (2)The frequency of BRCA1 mutation in 70 Uigur women breast cancer cases was 12.86% (9/70). The frequency of BRCA1 mutation in Uigur women early onset breast cancer was 31.82% (7/22), which was significantly higher than that in late onset group (2/48, 4.16%) (chi(2) =10.295, P<0.01). (3) There were BRCA1 gene polymorphisms in 9 of 70 Uigur women breast cancer patients. The loci of polymorphisms in 8 of 9 cases were 3232A>G. (4)In the research group two cases of bilateral breast cancer were found with BRCA1 gene mutation.</p><p><b>CONCLUSION</b>The mutation of BRCA1 gene may be related to Uigur women breast cancer and bilateral breast cancer.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neoplasias de la Mama
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Intrones
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Etnicidad
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China
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Polimorfismo Conformacional Retorcido-Simple
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Genes BRCA1
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Pueblo Asiatico
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Genética
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Mutación
Límite:
Adult
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Aged
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Female
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Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Article