Effects of carvedilol on neurohormone and magnesium metabolism in patients with chronic heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 995-997, 2005.
Article
en Zh
| WPRIM
| ID: wpr-253024
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of carvedilol on neurohormone and magnesium metabolism in patients with chronic heart failure (CHF).</p><p><b>METHODS</b>Fifty-seven patients with CHF were divided into two groups randomly: received conventional treatment alone or combined with carvedilol for 8 weeks, respectively. Urine magnesium excretion (UME), plasma levels of magnesium (PMC), norepinephrine (NE), angiotensin-II (Ang-II), aldosterone (ALD), plasma renin activity (PRA) and peripheral monocyte magnesium content (MMC) were measured before and after treatments. Twenty-six health persons were selected as normal subjects.</p><p><b>RESULTS</b>There was a significant increase in UME and plasma concentrations of NE, ALD, Ang-II and PRA, and a significant decrease in MMC in patients with CHF, compared with the control group (P < 0.01). UME was positively correlated with ALD, Ang-II, PRA r = 0.41, 0.42, 0.38, respectively (P < 0.01). These parameters significantly improved after carvedilol (P < 0.05).</p><p><b>CONCLUSION</b>Carvedilol decreases significantly plasma concentrations of neurohormone and urine magnesium excretion, and increases cell magnesium content in patients with CHF.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Propanolaminas
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Sangre
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Angiotensina II
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Carbazoles
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Norepinefrina
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Antagonistas Adrenérgicos beta
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Péptido Natriurético Encefálico
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Usos Terapéuticos
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Quimioterapia
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Aldosterona
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Año:
2005
Tipo del documento:
Article