Study on solid dispersion of binary vector of tanshinone II A / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1383-1387, 2012.
Article
en Zh
| WPRIM
| ID: wpr-267012
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare the solid dispersion of tanshinone II A (TS II A) by the combined application of nano-silica and poloxamer 188 (F68), in order to observe its dissolution and stability.</p><p><b>METHOD</b>Tanshinone II A solid dispersion was prepared by the solvent method with nano-silica and poloxamer 188 as binary vectors. Its physical characteristics, in vitro dissolution and stability were further assessed.</p><p><b>RESULT</b>The tanshinone II solid dispersion was prepared with the weight ratio of nano-silica and poloxamer 188 of 1 3. The differential scanning calorimetry (DSC) demonstrated that Tanshinone II A existed in vectors as amorphous state. The in vitro dissolution of tanshinone II A solid dispersion is up to 90% at 60 min. Accelerating experiment showed that content and in vitro dissolution of tanshinone II A solid dispersion did not change after storage over 3 months.</p><p><b>CONCLUSION</b>Solid dispersion of binary vector of tanshinone II A can obviously improve the dissolution and stability of tanshinone II in practice.</p>
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Base de datos:
WPRIM
Asunto principal:
Solubilidad
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Rastreo Diferencial de Calorimetría
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Medicamentos Herbarios Chinos
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Química
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Abietanos
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Estabilidad de Medicamentos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2012
Tipo del documento:
Article