Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake / 南方医科大学学报
Journal of Southern Medical University
; (12): 595-600, 2012.
Article
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| WPRIM
| ID: wpr-267543
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of N-Methyl-D-aspartic acid (NMDA)-type glutamate receptors in the central nucleus of the amygdale (CeA) in food and water intake.</p><p><b>METHODS</b>Male Sprague-Dawley rats with stainless steel cannulae implanted unilaterally into the CeA were used. The prototypic NMDA receptor agonist NMDA, or the selective NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5) was microinjected into the CeA of satiated and euhydrated rats.</p><p><b>RESULTS</b>Intra-CeA injection of 8.50, 17.00, or 34.00 nmol NMDA did not alter food intake but significantly increased water intake 0-1 h after the injection (F(3,32)=3.191, P=0.037) independent of food intake. Without affecting the food intake, injection of 6.34, 12.70, or 25.40 nmol D-AP-5 into the CeA significantly decreased water intake 0-1 h after the injection (F(3,28)=3.118, P=0.042) independent of food intake.</p><p><b>CONCLUSION</b>NMDA receptors in the CeA may participate in the control of water intake rather than food intake.</p>
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Base de datos:
WPRIM
Asunto principal:
Farmacología
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2-Amino-5-fosfonovalerato
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N-Metilaspartato
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Ratas Sprague-Dawley
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Receptores de N-Metil-D-Aspartato
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Antagonistas de Aminoácidos Excitadores
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Agonistas de Aminoácidos Excitadores
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Ingestión de Líquidos
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Ingestión de Alimentos
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Amígdala del Cerebelo
Límite:
Animals
Idioma:
En
Revista:
Journal of Southern Medical University
Año:
2012
Tipo del documento:
Article