The Antibiotic Resistance Pattern of Gram-Negative Bacteria in Children Younger Than 24 Months with a Urinary Tract Infection: A Retrospective Single-Center Study over 15 Consecutive Years
Childhood Kidney Diseases
; : 148-153, 2015.
Article
en En
| WPRIM
| ID: wpr-27106
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: We investigated trends in antibiotic resistance for gram-negative bacteria in infants with a urinary tract infection (UTI) over 15 years at a single institution. METHODS: A retrospective chart review was conducted for children younger than 24 months who visited the emergency room and were diagnosed with a UTI between January 2000 and December 2014. We selected urine culture data that grew Escherichia coli and Klebsiella pneumoniae. Baseline clinical information and results of antimicrobial susceptibility tests were analyzed by dividing the 15-year study time frame into three periods (A: 2000-2004, B: 2005-2009, and C: 2010-2014). RESULTS: During the study period, 478 applicable children were identified (E. coli, 89.7% and K. pneumoniae, 10.3%). Antibiotic resistance to third-generation cephalosporins was increased from period A to period C (A, 2.1%; B, 8.3%; C, 8.8%; P=0.025). Resistance to quinolones also showed a steady pattern during periods A to C, although it was not statistically significant (A, 7.9%; B, 9.7%; C, 12.4%; P=0.221). The incidence of Extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacteria increased from period A to period C (A, 1.4%; B, 7.6%; C, 8.2%; P=0.012). CONCLUSION: This study revealed that the common uropathogens E. coli and K. pneumoniae experienced increasing resistance rates against third-generation cephalosporins and a constant antibiotic resistance to quinolones in children younger than 24 months. We also showed a recent increased incidence of ESBL-producing gram-negative bacteria in patients with community-acquired UTIs. Therefore, it is necessary to actively surveil resistance in order to properly select empirical antibiotics.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neumonía
/
Sistema Urinario
/
Infecciones Urinarias
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Beta-Lactamasas
/
Farmacorresistencia Microbiana
/
Cefalosporinas
/
Incidencia
/
Estudios Retrospectivos
/
Quinolonas
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Servicio de Urgencia en Hospital
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
Childhood Kidney Diseases
Año:
2015
Tipo del documento:
Article