Clinical features and prognosis of t (8; 21)/AML1-ETO-positive childhood acute myeloid leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 931-935, 2011.
Article
en Zh
| WPRIM
| ID: wpr-272429
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>UNLABELLED</b>OBJECTIVE To study the clinical and biological characteristics and prognosis of t(8;21)/AML1-ETO-positive childhood acute myeloid leukemia (AML).</p><p><b>METHODS</b>The clinical data of 55 children who were diagnosed as t (8; 21)/AML1-ETO-positive AML were retrospectively studied. Event-free survival (EFS), disease-free survival (DFS), and overall survival (OS) rates were estimated by the Kaplan-Meier method. Prognostic factors were evaluated by COX regression analysis software.</p><p><b>RESULTS</b>Of the 55 patients, 4 patients gave up treatment after the diagnosis was confirmed and 4 patients were lost to follow-up after the first chemotherapy course. The remaining 47 patients received a double-induction therapy. The total complete remission (CR) rate was 71% and 94% after the first and second chemotherapy course, respectively. The disease was relapsed in 10 patients (21%). The 5-year EFS, DFS and OS rates were (56.1 ± 7.9)%, (59.8 ± 8.1)%, and (72.0 ± 8.1)%, respectively. Multivariate analysis showed that age was an independent risk factor for the long-term prognosis. The older children had a greater risk of experiencing an accident or death (P<0.05). The 5-year OS rate in 27 patients with regular consolidation chemotherapy was significantly higher than 13 patients with irregular chemotherapy after CRz [(47.5 ± 17.1)% vs (38.9 ± 17.3)%; P<0.01].</p><p><b>CONCLUSIONS</b>Childhood t(8;21)/AML1-ETO-positive AML is a highly heterogeneous disease, with a high CR rate and a good long-term prognosis. Age is one of the important factors affecting the long-term therapeutic effect. Regular consolidation chemotherapy applied after CR usually is helpful.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
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Translocación Genética
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Examen de la Médula Ósea
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Cromosomas Humanos Par 8
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Cromosomas Humanos Par 21
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Leucemia Mieloide Aguda
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Proteínas de Fusión Oncogénica
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Mortalidad
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Subunidad alfa 2 del Factor de Unión al Sitio Principal
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Proteína 1 Compañera de Translocación de RUNX1
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2011
Tipo del documento:
Article