The incidence of pelvic and para-aortic lymph node metastasis in uterine papillary serous and clear cell carcinoma according to the SEER registry / 부인종양
Journal of Gynecologic Oncology
; : 19-24, 2015.
Article
en En
| WPRIM
| ID: wpr-27946
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: In this study we utilized the Surveillance, Epidemiology and End-Results (SEER) registry to identify risk factors for lymphatic spread and determine the incidence of pelvic and para-aortic lymph node metastases in patients with uterine papillary serous carcinoma (UPSC) and uterine clear cell carcinoma (UCCC) who underwent complete surgical staging and lymph node dissection. METHODS: Nine hundred seventy-two eligible patients diagnosed between 1998 to 2009 with International Federation of Gynecology and Obstetrics (FIGO) 1988 stage IA-IVA UPSC (n=685) or UCCC (n=287) were identified for analysis. Binomial logistic regression was used to determine risk factors for lymph node metastasis, with the incidence of pelvic and para-aortic lymph node metastases reported for each FIGO primary tumor stage. The Cox proportional hazards regression model was used to determine factors associated with overall survival. RESULTS: FIGO primary tumor stage was the only independent risk factor for lymph node metastasis (p60 years (HR, 1.70; 95% CI, 1.21 to 2.41; p<0.01), and advanced FIGO primary tumor stage (p<0.01). Tumor grade, histologic subtype, and patient race did not predict for either lymph node metastasis or overall survival. CONCLUSION: There is a high incidence of both pelvic and para-aortic lymph node metastases for FIGO stages IC and above uterine papillary serous and clear cell carcinomas, suggesting a potential role for lymph node-directed therapy for these patients.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Aorta Abdominal
/
Pelvis
/
Estados Unidos
/
Neoplasias Uterinas
/
Incidencia
/
Cistadenocarcinoma Seroso
/
Cistadenocarcinoma Papilar
/
Adenocarcinoma de Células Claras
/
Programa de VERF
/
Estimación de Kaplan-Meier
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Journal of Gynecologic Oncology
Año:
2015
Tipo del documento:
Article