Expression of TGFbeta1 and its type I receptors ALK1 and ALK5 mRNA in brain arteriovenous malformation / 南方医科大学学报
Journal of Southern Medical University
; (12): 675-677, 2006.
Article
en Zh
| WPRIM
| ID: wpr-282948
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of transforming growth factor beta1 (TGFbeta1) and its type I receptors activin-like kinase 1 (ALK1) and ALK5 mRNA in the development of brain arteriovenous malformation (BAVM).</p><p><b>METHODS</b>The mRNA expressions of TGFbeta1, ALK1and ALK5 were detected with semiquantitative RT-PCR in patients with BAVM.</p><p><b>RESULTS</b>The expressions of TGFbeta1 and ALK5 mRNA increased significantly in BAVM, and their relative expression quantity were 0.777-/+0.047 and 0.585-/+0.074, respectively. However, ALK1 mRNA expression declined significantlies with a relative expression of 0.173-/+0.044 in comparison with the control group (0.720-/+0.098, P<0.01).</p><p><b>CONCLUSION</b>The balance of TGFbeta1 and its type I receptors ALK1 and ALK5 mRNA expressions may play important role in the development of BAVM.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Encéfalo
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ARN Mensajero
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Expresión Génica
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Malformaciones Arteriovenosas Intracraneales
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Proteínas Serina-Treonina Quinasas
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Receptores de Factores de Crecimiento Transformadores beta
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Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
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Receptores de Activinas Tipo II
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Factor de Crecimiento Transformador beta1
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Article