Research advances in CKLF-like MARVEL transmembrane domain containing member 5 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 625-628, 2012.
Article
en Zh
| WPRIM
| ID: wpr-284319
Biblioteca responsable:
WPRO
ABSTRACT
CKLF-like MARVEL transmembrane domain containing member(CMTM)is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily(TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Transducción de Señal
/
Quimiocinas
/
Proteínas Supresoras de Tumor
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Proteínas con Dominio MARVEL
/
Genética
/
Metabolismo
/
Neoplasias
Límite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2012
Tipo del documento:
Article
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA