Analysis of DC-SIGN and DC-SIGNR genetic polymorphism in Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 466-469, 2006.
Article
en Zh
| WPRIM
| ID: wpr-285097
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To understand the genetic polymorphism of DC-SIGN's and DC-SIGNR's neck regions in normal Chinese Han population, and to obtain the genetic data of the two loci in Chinese Han population.</p><p><b>METHODS</b>The genotypes and alleles of repeat sequences of DC-SIGN and DC-SIGNR neck region were typed by PCR, agarose gel electrophoresis and sequencing. Polymorphism information content (PIC) of DC-SIGNR was calculated.</p><p><b>RESULTS</b>DC-SIGN genetic polymorphism was rare. Allele 7 was most and its frequency was 0.9808. 4-, 5-, 6- and 8- alleles were also found, although their frequencies were very low. Caucasians had only 6- and 8- allele mutants; DC-SIGNR genetic polymorphism was high, its PIC was 0.5312, 4-,5-,6-,7-,8-,9- alleles and 16 genotypes were found in normal Chinese Han population. The differences of 6/5,7/4,7/5,7/6,7/7,9/5,9/7,9/9 genotypes distribution and 5-,6-,7-,9- alleles frequency between normal Chinese Han population and Caucasian population were all extremely distinct (P<0.01). The inserted mutation seemed more in Chinese Hans than Caucasian population.</p><p><b>CONCLUSION</b>DC-SIGN and DC-SIGNR genotypes and alleles distribution in Chinese Han population are significantly different from Caucasian population and with Chinese own population genetic characteristics, compared with Caucasians.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Moléculas de Adhesión Celular
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China
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Reacción en Cadena de la Polimerasa
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Receptores de Superficie Celular
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Lectinas Tipo C
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Pueblo Asiatico
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Alelos
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Frecuencia de los Genes
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Genética
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2006
Tipo del documento:
Article
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA