Determinants of late-stage HIV disease at diagnosis in Singapore, 1996 to 2009
Annals of the Academy of Medicine, Singapore
; : 194-199, 2012.
Article
en En
| WPRIM
| ID: wpr-299658
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>The delay in HIV diagnosis has been identified as a significant reason for late presentation to medical care. This research aims to elucidate the significant determinants of late-stage HIV infection in Singapore between 1996 and 2009, after the advent of highly active anti-retroviral therapies.</p><p><b>MATERIALS AND METHODS</b>We included 3735 patients infected via sexual mode of transmission from the National HIV Registry diagnosed between 1996 and 2009. Late-stage HIV infection is defined as CD4 count less than 200 mm(3) or AIDS-defining opportunistic infections at fi rst diagnosis or within one year of HIV diagnosis. We determined independent epidemiological risk factors for late-stage HIV infection at first diagnosis using multivariate logistic regression.</p><p><b>RESULTS</b>Multivariate analysis showed that older age corresponded significantly with increasing odds of late-stage HIV infection. Compared to persons diagnosed at 15 to 24 years of age, those diagnosed at age 55 years and above were associated with 5-fold increased likelihood of late-stage infection (adjusted odds ratio (AOR): 5.17; 95% CI, 3.21 to 8.33). Chinese ethnicity, singlehood, and non-professional occupations were also significantly associated with late-stage HIV infection. Persons detected in the course of medical care had over 3.5 times the odds of late-stage infection (AOR: 3.55; 95% CI, 2.71 to 4.65). Heterosexual mode of transmission and having sex workers and social escorts as sexual partners, were the other epidemiological risk factors with significant associations.</p><p><b>CONCLUSION</b>The findings of this study emphasises the need to increase HIV awareness and to encourage early and regular HIV testing among at-risk persons.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Conducta Sexual
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Singapur
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Infecciones por VIH
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Modelos Logísticos
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Sistema de Registros
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Epidemiología
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Estudios Retrospectivos
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Factores de Riesgo
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Factores de Edad
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VIH
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2012
Tipo del documento:
Article