In vitro transdermal delivery of Qingfei Xiaocuo gel based on principal component analysis / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 231-235, 2015.
Article
en Zh
| WPRIM
| ID: wpr-305317
Biblioteca responsable:
WPRO
ABSTRACT
The objective of the present study was to establish a method based on principal component analysis (PCA) for the study of transdermal delivery of Chinese medicinal formulae, and to choose the best penetration enhancers for Qingfei Xiaocuo gel depend on this method. Using improved Franz type diffusion cell and excised rat skin in vitro as transdermal barrier, the receptive solution fingerprint was established by HPLC, harvesting the areas of the common peaks in the fingerprint, then the total factor scores of the concentrations at different times were calculated using PCA and were employed instead of the concentrations to compute the cumulative amounts (Q12) and enhancement ratio (ER), the latter of which were considered as the indexes for optimizing penetration enhancers. Compare to the control group, the ER of the other groups increased significantly and furthermore, 2.5% azone with 2.5% menthol manifested the best effect. PCA represent most information in the receptive solution, the method above could choose the best penetration enhancers, it could be a reference for the study of transdermal delivery of Chinese medicinal formulae.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Piel
/
Técnicas In Vitro
/
Administración Cutánea
/
Medicamentos Herbarios Chinos
/
Farmacocinética
/
Análisis de Componente Principal
/
Geles
/
Medicina Tradicional China
/
Metabolismo
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2015
Tipo del documento:
Article