Diagnostic value of serum Cystatin C in renal function impairments in children with viral encephalitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 119-122, 2011.
Article
en Zh
| WPRIM
| ID: wpr-308859
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the value of serum Cystatin C (Cyst C) in the evaluation of glomerular filtration function in children with viral encephalitis.</p><p><b>METHODS</b>Serum levels of Cyst C, urea nitrogen (BUN) and creatinine (Cr) were measured in 92 children with viral encephalitis and in 50 healthy children as a control group. According to glomerular filtration rate (GFR), the encephalitis group was subdivided into normal renal function, renal insufficiency in the compensatory or decompensatory stage, and renal failure /end-stage groups.</p><p><b>RESULTS</b>Serum levels of Cyst C, BUN and Cr in the encephalitis group increased and GFR decreased significantly compared with those in the control group (P<0.01). With the decline of renal function, GFR decreased and serum levels of Cyst C, BUN and Cr increased gradually. Serum levels of Cyst C and GFR were significantly different among the encephaitis subgroups (P<0.01). For serum levels of BUN and Cr, there were significant differences among the subgroups except between the normal renal function and the compensatory renal insufficiency groups. Serum Cyst C level was positively correlated with serum BUN and Cr levels, and negatively correlated with GFR.</p><p><b>CONCLUSIONS</b>The children with viral encephalitis have different degrees of renal impairments. Cyst C appears to be superior to BUN and Cr as a marker for the evaluation of glomerular filtration function. Measurement of serum Cyst C levels is very valuable in renal function monitoring in children with viral encephalitis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Sangre
/
Encefalitis Viral
/
Diagnóstico
/
Insuficiencia Renal
/
Cistatina C
/
Tasa de Filtración Glomerular
Tipo de estudio:
Diagnostic_studies
Límite:
Child
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Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2011
Tipo del documento:
Article