DAZL and male infertility: an update / 中华男科学杂志
National Journal of Andrology
; (12): 647-650, 2014.
Article
en Zh
| WPRIM
| ID: wpr-309660
Biblioteca responsable:
WPRO
ABSTRACT
DAZL, a member of the DAZ family, plays a key role in human spermatogenesis. It regulates the promoter via genetic modification, especially DNA methylation, promoting the transcription of DAZL. Besides, the relation of DAZL SNPs with male infertility has been a hot spot of research for many years. It is deduced that local and ethnic factors may be associated with the failure of spermatogenesis. This article presents an overview on the results of recent studies, changes in the DNA methylation of DAZL in spermatogenesis, and the association of DAZL SNPs with male infertility, aiming to provide a new theoretical basis and clinical strategy for the treatment of male infertility.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Espermatogénesis
/
Proteínas de Unión al ARN
/
Metilación de ADN
/
Polimorfismo de Nucleótido Simple
/
Genética
/
Infertilidad Masculina
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2014
Tipo del documento:
Article