Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 156-160, 2008.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-310777
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.</p><p><b>METHODS</b>The intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.</p><p><b>RESULTS</b>Neointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.</p><p><b>CONCLUSION</b>Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Sesquiterpenos
/
Endotelio Vascular
/
Ratas Sprague-Dawley
/
Inhibidor Tisular de Metaloproteinasa-2
/
Metaloproteinasa 2 de la Matriz
/
Neointima
/
Hiperplasia
/
Metabolismo
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2008
Tipo del documento:
Artículo