Analgesic and anti-inflammatory effects of UP1304, a botanical composite containing standardized extracts of Curcuma longa and Morus alba / 中西医结合学报
Journal of Integrative Medicine
; (12): 60-68, 2016.
Article
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| WPRIM
| ID: wpr-317047
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Though the initial etiologies of arthritis are multifactorial, clinically, patients share the prime complaints of the disease, pain. Here the authors assessed the analgesic and anti-inflammatory effects of UP1304, a composite that contains a standardized blend of extracts from the rhizome of Curcuma longa and the root bark of Morus alba, on rats with carrageenan-induced paw edema.</p><p><b>METHODS</b>A plant library was screened for bradykinin receptor antagonists. In vivo, the anti-inflammatory and analgesic effects of the standardized composite, UP1304, were evaluated in rats with carrageenan-induced paw edema using oral dose ranges of 100-400 mg/kg. Ibuprofen, at a dose of 200 mg/kg, was used as a reference compound. In vitro, cyclooxygenase (COX) and lipoxygenase (LOX) inhibition assays were performed to evaluate the degree of inflammation.</p><p><b>RESULTS</b>Statistically significant improvements in pain resistance and paw edema suppression were observed in animals treated with UP1304, when compared to vehicle-treated rats. Results from the highest dose of UP1304 (400 mg/kg) were similar to those achieved by ibuprofen treatment at 200 mg/kg. In vitro, UP1304 showed dose-dependent inhibition of the enzymatic activities of COX and LOX. A half-maximal inhibitory concentration of 9.6 μg/mL for bradykinin B1 inhibition was calculated for the organic extract of C. longa. Curcumin showed Ki values of 2.73 and 58 μg/mL for bradykinin receptors B1 and B2, respectively.</p><p><b>CONCLUSION</b>Data presented here suggest that UP1304, analgesic and anti-inflammatory agent of botanical origin, acted as a bradykinin receptor B1 and B2 antagonist, and inhibited COX and LOX enzyme activities. This compound should be considered for the management of symptoms associated with arthritis.</p>
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Base de datos:
WPRIM
Asunto principal:
Farmacología
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Ratas Endogámicas Lew
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Extractos Vegetales
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Inhibidores de la Ciclooxigenasa
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Curcuma
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Morus
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Relación Dosis-Respuesta a Droga
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Analgésicos
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Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Journal of Integrative Medicine
Año:
2016
Tipo del documento:
Article