Clinical trial on the prevention of diarrhea by oral BIFICO for infants aged 1-6 years / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 277-279, 2013.
Article
en Zh
| WPRIM
| ID: wpr-318043
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the prevention of diarrhea by oral BIFICO for infants aged 1-6 years.</p><p><b>METHODS</b>490 cases of infants were randomly divided after age stratification the experimental group (n = 247) and the control group (n = 243). Based on principles of randomized double-blind and placebo-controlled, the infants were given BIFICO (dedicated clinical research)therapy for 4 consecutive days, then observed for 21 days. 25 days composed a cycle. They were observed total 5 cycles. During the study period, principles for "the diarrhoea patients must be detected", follow-up visited the participant infants and conducted etiology detection by way of sampling for diarrhea infants. Evaluate the prevention efficacy of diarrhea by oral BIFICO for infants aged 1-6 years.</p><p><b>RESULTS</b>A total of 480 completed all study. 120 and 95 infants in the control group and experimental group were detected with diarrhea. The incidence of diarrhea was 50.85% and 38.93% in these two guoup, respectively. The difference has statistical significance (chi2 = 4.175, P = 0.041). In the third observation period, the infants in the control group had a higer incidence of diarrhea compared with which in the experimental group (chi2 = 4.415, P = 0.036). 14 strains of rotavirus, 3 strains of norovirus, 3 strains of sappovirus, 2 strains of adenovirus, 5 strains of salmonella and 4 strains of Shigella were check out in 128 samples.</p><p><b>CONCLUSION</b>Oral BIFICO can paly certain preventive role on diarrhea, and decrease the incidence of diarrhea in infants aged 1-6 years.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Incidencia
/
Administración Oral
/
Probióticos
/
Diarrea
/
Quimioterapia
Tipo de estudio:
Clinical_trials
/
Incidence_studies
/
Prognostic_studies
Límite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2013
Tipo del documento:
Article