Protein compositions in the seminal plasma are similar between severe oligospermic and healthy fertile men / 中华男科学杂志
National Journal of Andrology
; (12): 298-302, 2008.
Article
en Zh
| WPRIM
| ID: wpr-319266
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyse the variability of proteins in the seminal plasma of severe oligospermic and healthy fertile men.</p><p><b>METHODS</b>Spermatic fluid samples were collected from 11 healthy fertile men and 6 severe oligospermic male volunteers and tested by SELDI-TOF-MS with the CM10 protein chip to get the protein spectra maps, which were automatically treated with the special softwares of Ciphergen Inc.</p><p><b>RESULTS</b>The mean peak heights of 2 lower-abundance proteins expressed in the seminal plasma of the severe oligospermic men were statistically different from the healthy fertile males (P<0.05). Fifteen different proteins existed between the nonobstructive azoospermic and the severe oligospermic group, 7 of which, with m/z of 7,196.058, 7,547.610, 5,780.493, 7,059.844, 7,409.589, 5,379.173 and 10,778.810, also between the non-obstructive azoospermic and the healthy fertile males (P<0.05). Except the latter two, the contents of the other 5 proteins were decreased in the non-obstructive azoospermic men (P<0.05).</p><p><b>CONCLUSION</b>The finger prints of the seminal plasma proteins of the severe oligospermic group were similar to those of the healthy fertile males, both significantly different from the non-obstructive azoospermic men. It is suggested that pathogenesis mechanisms differ exist between non-obstructive azoospermia and severe oligospermia but are not the simple accumulation of genetic factors.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Oligospermia
/
Semen
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Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
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Proteínas de Plasma Seminal
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Metabolismo
Límite:
Adult
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Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2008
Tipo del documento:
Article
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA