Expression of microRNA-183 in stage II ( gastric cancer and its association with Ezrin protein / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 723-726, 2012.
Article
en Zh
| WPRIM
| ID: wpr-321539
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of microRNA-183 (miR-183) and Ezrin protein in stage II( gastric cancer (GC).</p><p><b>METHODS</b>Specimens of stage II( GC and paracancer tissues (5 cm away from the tumor tissues) were collected from 72 patients. Real-time PCR was used to detect the miR-183 expression. Immunohistochemistry was used to examine the Ezrin protein expression in the tumor tissue. The associations of miR-183 expression with the clinicopathologic features of stage II( GC and Ezrin expression were analyzed.</p><p><b>RESULTS</b>miR-183 expression was lower in stage II( gastric cancer tissues compared with the paracancer tissues samples(median relative expression, 0.676 vs. 1.000, P<0.05). Low expression of miR-183 was significantly associated with histological differentiation(0.429 vs. 0.907, P<0.05), lymph node metastasis(0.507 vs. 0.908, P<0.05). The survival was shorter in patient with low expression of miR-183(63.0±4.0) as compared to those with high expression of miR-183(75.2±3.8)(P<0.05). There was a negative correlation between the expression of miR-183 and Ezrin(r=-0.272, P<0.05).</p><p><b>CONCLUSIONS</b>miR-183 is down-regulated in stage II( GC, and associated with the differentiation, metastasis, and prognosis. Ezrin is a potential regulatory protein of miR-183.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Pronóstico
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Neoplasias Gástricas
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Proteínas del Citoesqueleto
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MicroARNs
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Genética
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Metabolismo
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Metástasis de la Neoplasia
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Estadificación de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2012
Tipo del documento:
Article