Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice.</p><p><b>METHODS</b>We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining.</p><p><b>RESULTS</b>Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes.</p><p><b>CONCLUSION</b>The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.</p>