Impact of drug molecules on HP-β-CD compound inclusion / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2893-2899, 2014.
Article
en Zh
| WPRIM
| ID: wpr-327872
Biblioteca responsable:
WPRO
ABSTRACT
To study the interaction of drugs of different properties, namely puerarin, borneol and catalpol in the process of in- clusion, in order to explore the inclusion regularity of multi-component and multi-property traditional Chinese medicine compound in- clusions. With HP-β-CD as the inclusion material, the freeze-drying method was used to prepare the inclusion. The inclusion between puerarin, borneol and catalpol was tested by measuring the inclusion concentration, DSC and X-ray diffraction. According to the find- ings, when insoluble drugs puerarin and borneol were included simultaneously, and puerarin was overdosed, puerarin included was almost equal to puerarin included, and borneol was not included. When puerarin was under-dosed, and HP-β-CD was overdosed, borne- ol was included, and the simultaneous inclusion was lower than the separate inclusion of borneol. When water-soluble drug catalpol was jointly included with puerarin or borneol, the simultaneous inclusion was almost the same with their separate inclusion, without charac- teristic peak of catalpol in DSC and X-ray diffraction patterns. There is a competition in the simultaneous inclusion between water-solu- ble drugs puerarin and borneol and a stronger competition in puerarin. The water-soluble drug catalpol could be included with HP-β-CD with no impact on the inclusion of puerarin or borneol.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Solubilidad
/
Canfanos
/
Isquemia Encefálica
/
Química
/
Usos Terapéuticos
/
Beta-Ciclodextrinas
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Composición de Medicamentos
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Quimioterapia
/
Glucósidos Iridoides
/
2-Hidroxipropil-beta-Ciclodextrina
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2014
Tipo del documento:
Article