Research progress on second-hit in malignant lymphomagenesis-- review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1627-1631, 2010.
Article
en Zh
| WPRIM
| ID: wpr-332304
Biblioteca responsable:
WPRO
ABSTRACT
Stem/progenitor cells contribute to normal development of organs, but their mutation may lead to many human diseases including cancer. Stem/progenitor cells and some of the cancer cells have the same abilities of self-renewal and differentiation, suggesting that tumors were initiated from mutated stem/progenitor cells, the cancer stem/progenitor cells. The recent studies on the origin of the non-Hodgkin's lymphomas has proved that the second-hit aggravates gene mutation in lymphocytic progenitor cells, leading to the generation of lymphoma. This review summarizes the current advances in the studies of the second-hit at stem/progenitor cells in oncogenesis of B-cell non-Hodgkin's lymphoma.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Células Madre Neoplásicas
/
Leucemia
/
Biología Celular
/
Linfoma
/
Mutación
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2010
Tipo del documento:
Article