Polymorphism of 17 short tandem repeat Loci of Tibetan minority ethnic group from Lhasa / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 397-401, 2011.
Article
en Zh
| WPRIM
| ID: wpr-341395
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the polymorphism of 17 short tandem repeat (STR) loci of Tibetan minority ethnic group from Lhasa.</p><p><b>METHODS</b>Blood samples were obtained from 132 unrelated Tibetan individuals from Lhasa. DNA templates were screened by home-made AGCU17+1 kit and 3130XL genetic analyzer. Genotyping was performed using GeneMapper software (version 3.2).</p><p><b>RESULTS</b>The allele frequencies of 17 STR loci ranged 0.0038-0.5720, and the power of discrimination ranged 0.779-0.979, the power of exclusion ranged 0.327-0.737, the polymorphism information contents ranged 0.538-0.910, and the heterozygosity ranged 0.629-0.871. The cumulative coupling probability was 3.93 × 10(-20), and the cumulative power of exclusion was 0.9999995234. Of 17 STR loci, Penta E and D6S1043 had the highest polymorphism indicators, while TPOX had the lowest.</p><p><b>CONCLUSION</b>The 17 STR loci used in this study are highly polymorphism in Tibetan minority ethnic group from Lhasa and fit for the population genetic study and forensic cases.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Polimorfismo Genético
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Etnicidad
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Tibet
/
Repeticiones de Microsatélite
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Pueblo Asiatico
/
Frecuencia de los Genes
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Genética
/
Genotipo
/
Grupos Minoritarios
Aspecto:
Determinantes_sociais_saude
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2011
Tipo del documento:
Article