Morphometry of osteoclasts in experimental fracture healing of rabbits / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 889-893, 2007.
Article
en Zh
| WPRIM
| ID: wpr-346048
Biblioteca responsable:
WPRO
ABSTRACT
This study was designed to investigate the effects of some Traditional Chinese Medicine (TCM) agents on bone resorption and morphometric features of osteoclasts as well as their relationships. TCM ShengGuZaiZaoSan and XianLingGuBao, were used to treat the experimental fracture. Thirty 6-month-old Chinchilla rabbits were used for the establishment of animal models each with a 3 mm bone defect in the middle of left radius as well as of right radius. These models were divided randomly into 3 groups : ShengGuZaiZaoSan Group (Group A), XianLingGuBao groups (Group B) and control-group (Group C). Every group was further divided into 2 subgroups: a former sacrificed group (14 days after operation) and a latter sacrificed group (31 days after operation). After the rabbits being killed, the samples of their undecalcified calli were subjected to the morphometry study of bone resorption and osteoclasts. Group A had more bone resorption, compared with Group B and C. Both Groups A and B exhibited some changed morphometric features of osteoclasts as compared with Group C (P < 0.05). Simple correlation analysis indicated that bone resorption is mainly correlated with osteoclast numbers, and that in individual group, bone resorption is correlated with osteoclast form factor, area and mean photodensity (P < 0.05). These allow us to conclude that ShengGuZaiZaoSan can increase bone resorption and accelerate bone remodeling by increasing osteoclast numbers at the former stage and can enhance osteoclast function at the latter stage. These changes are beneficial to fracture healing.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoclastos
/
Patología
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Farmacología
/
Fisiología
/
Fracturas del Radio
/
Resorción Ósea
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Medicamentos Herbarios Chinos
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Distribución Aleatoria
/
Remodelación Ósea
/
Curación de Fractura
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Año:
2007
Tipo del documento:
Article