Correlation of autoantibodies against oxidized low density lipoprotein and its immune complex with coronary artery disease / 浙江大学学报·医学版

ABSTRACT

OBJECTIVE: To evaluate the relationship between autoantibodies against oxidized low density lipoprotein(ox- LDL), immune complex and coronary artery disease(CAD). METHODS: The levels of autoantibodies against ox-LDL and immune complex were assayed by ELISA, the content of ox-LDL and lipid levels were also measured. The serum samples were taken from 61 patients with CAD, 116 patients with essential hypertension(EH) and 123 healthy individuals as control. RESULTS: The patients with CAD had significantly higher levels of anti-ox-LDL IgG[21.48(17.58 approximate, equals 29.01)U/L], anti-ox-LDL IgM4.71[3.88 approximate, equals 7.06)U/L] and ox-LDL[0.87(0.44 approximate, equals 1.08) mg/L] than EH group[15.93(11.12 approximate, equals 22.26) U/L 2.54(1.17 approximate, equals 5.05) U/L 0.32(0.16 approximate, equals 0.61) mg/L]and healthy control group[11.12(4.70 approximate, equals 16.57)U/L 1.61(0.60 approximate, equals 3.03)U/L 0.23(0.12 approximate, equals 0.36)mg/L], P<0.001. However, the serum ox-LDL immune complex[2.63(1.69 approximate, equals 5.90)U/L] was significantly lower in CAD than that in EH group[15.71(6.25 approximate, equals 28.74)U/L] and that in healthy control group[12.54(8.28 approximate, equals 23.90)U/L], P<0.001. There were discrepancies in the association between ox-LDL and autoantibodies against ox-LDL among different groups. CONCLUSION: The changes of autoantibodies against ox-LDL and immune complex in patients with CAD may be related to the role of ox-LDL and autoantibodies against ox-LDL in the process of coronary atherosclerosis.